Extended Data Fig. 6: Effect of myelomonocytic cell invasion on cerebral edema and survival after injury.
From: Temporally distinct myeloid cell responses mediate damage and repair after cerebrovascular injury
This figure depicts quantification of cerebral water content following anterior and posterior injury as well as survival after posterior injury in four different experimental paradigms. Left column shows quantification of cerebral water content in the ipsilateral hemisphere 1 d after anterior injury in the treatment vs control group compared to the contralateral hemisphere. The middle column shows quantification of cerebral water content after posterior injury when mice reached the survival end point or 5 d post-injury in the treatment vs. control group relative to the contralateral hemisphere (*P < 0.05, **P < 0.01, Two-way ANOVA/Holm-Sidak test). Graphs depict mean ± SD. The right column shows Kaplan-Meier survival curves after posterior injury in treatment vs. control groups (Log-rank test). a, Effect of αGr-1 vs. isotype control bolus administration 24 h prior to injury. b, Effect of αLFA1/VLA4 vs. isotype control bolus administration 24 h prior to injury. c, Water content and survival after injury in CCR2 KO mice compared to B6 mice treated with isotype or αLFA1/VLA4 24 h prior to injury. d, Effect of αLy6G or αLFA1/VLA4 vs. isotype control administration 24 h prior to injury. Data are representative of 2 independent experiments with 4 or 5 mice per group.
