Extended Data Fig. 8: ABC model predictions of inducible enhancer-gene associations.

a. The number of inducible genes and H3K27ac enhancer regions, as defined by this study (1G), predicted to interact by the Activity-by-Contact (ABC) model described in Fulco et al., Nat. Genetics, 2019. b. An example of one ASD-associated and neuronal activity-dependent gene locus, KCNQ3, as visualized in the IGV genome browser, with chromatin data presented in this resource (1G tracks below) and ABC model predictions of enhancer associations with the KCNQ3 promoter (arcs above). These include enhancer associations that remain constitutively predicted across all stimulation conditions (purple), those that are potentially transient but not necessarily activity-dependent (yellow), and those that are likely to be activity-dependent (red). In this case, at 15 minutes and 2 hours after neuronal depolarization, the KCNQ3 promoter is predicted to interact with an activity-dependent intronic enhancer (shaded), which increases in H3K27ac enrichment and becomes associated with the activated CREB-complex after depolarization. See Supplementary Data 13 for the full list of ABC model predicted enhancer-gene associations.