Extended Data Fig. 6: Quantifying activity-dependent regulatory elements.

a, Spearman’s correlation coefficients for terms included in models (Fig. 2f-i). b, c, Results of promoter-only (b) and promoter plus nearest enhancer (c) models for only genes that form loops to classified enhancers within 5C regions. N = 45 genes analyzed. d, R2 values of models presented in (b-c). e, Coefficients of each explanatory variable term in models presented in (b-c). t-statistic p-values and standard errors represented via stars and error bars, respectively. f–h, Acetylation heatmaps, pileups of classified activity-induced (f), activity-decommissioned (g), invariant (h) enhancers.