Extended Data Fig. 8: Expression of Bdnf transcripts. | Nature Neuroscience

Extended Data Fig. 8: Expression of Bdnf transcripts.

From: Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression

Extended Data Fig. 8

a, Depiction of the 12 RefSeq transcript isoforms of the Bdnf gene, above which we annotate the 8 promoters as in Hong et al., Neuron, 2008. b, Expression strip plots of each Bdnf isoform, organized in columns by shared promoter. N = 3, mean lines plotted. c, Boxplots overlaid by strip plots of count of opposing looping anchors that contain an activity-dependent enhancer for rapid immediate early genes (rIEGs, as defined as rPRGs in Tyssowski et al.9), translation-independent SRGs (tiSRGs, defined as dPRGs in Tyssowski et al.9), translation-dependent SRGs (tdSRGs, defined as SRGs in Tyssowski et al.9), and all genes. Boxes range from lower to upper quartile with median line, whiskers extend to min/max data point within 1.5*interquartile range.

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