Extended Data Fig. 9: Verification of the eRNA signature captures enhancer activity dynamics. | Nature Neuroscience

Extended Data Fig. 9: Verification of the eRNA signature captures enhancer activity dynamics.

From: Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression

Extended Data Fig. 9: Verification of the eRNA signature captures enhancer activity dynamics.

a, Genome browser view of ~50 kb window surrounding the Fos gene. Rows from top to bottom present: 1) RNA signal in active neurons from Kim et al. 12, 2) RNA signal in inactive neurons from Kim et al. 12, 3) RNA signal from neurons in the Bic condition, 4) RNA signal from neurons in the TTX condition, 5) H3K27ac ChIP-seq signal from neurons in the Bic condition, 6) H3K27ac ChIP-seq signal from neurons in the TTX condition. b, RNA-seq signatures at enhancers near Fos across 0, 5, 20, 60, and 360 minutes of acute neuron activation.

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