Extended Data Fig. 10: Foxp1 and Slc4a10 fall opposite disease-associated variants in conserved classified loops. | Nature Neuroscience

Extended Data Fig. 10: Foxp1 and Slc4a10 fall opposite disease-associated variants in conserved classified loops.

From: Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression

Extended Data Fig. 10

a, Number of loops called in HiC data obtained from human fetal cortical plate (CP) and germinal zone (GZ) tissue (Won et al.41). b, Interaction frequency heatmap (left) and thresholded loop calls (right) of the 2.5 Mb region surrounding the Bdnf gene in human cortical plate (CP) fetal tissue. c–e, Human (c) and mouse (d) interaction frequency heatmaps of a 2 Mb region surrounding the Foxp1 gene. The expression of the looping Foxp1 isoform labeled in green in (d) is plotted in (e). f–h, Human (f) and mouse (g) interaction frequency heatmaps of a < 2 Mb region surrounding the Slc4a10 gene (green), followed by expression of its 5 expressed isoforms (h). N = 3 RNA-seq replicates in (e,h), mean lines plotted.

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