Extended Data Fig. 7: HFD exposure promotes devaluation of optogenetic ARCAgRP-evoked SD, but not HFD, and consumption independent of weight gain.
From: High-fat food biases hypothalamic and mesolimbic expression of consummatory drives
a, Between-subject comparison of fedAgRP stimulation 1 hr SD consumption across test sessions (n = 16 SD group, n = 17 SD + HFD group, males and females, RM two-way ANOVA, Time x Group: F (4, 124) = 18.85, P < 0.0001, Bonferroni’s multiple comparisons). b, No correlation between SD devaluation at Week 8 relative to Baseline and body weight changes after 8 weeks of access to SD and HFD (n = 17, males and females, Linear regression, R2 = 0.04964, P = 0.3900). c, Within-subject, within-diet comparisons of fedAgRP stimulation 1 hr SD and HFD consumption across testing sessions (n = 17, males and females, RM one-way ANOVAs, Tukey’s multiple comparisons). B = Baseline. WD = Withdrawal. Shaded blue area in a and c represent HFD homecage availability. All error bars represent s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
