Extended Data Fig. 7: AAV9-mediated SMN overexpression induces cytoplasmic aggregation of SmB in motor circuit neurons of mouse models.
From: Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensorimotor circuit
a, ChAT and SmB immunostaining of L5 LMC MNs from uninjected and either AAV9-GFP (5) or AAV9-SMN (5) injected WT mice at P11 and P150. Scale bar=10 µm. b, PV and SmB immunostaining of L5 DRG PNs from the same groups as in (a). Scale bar=10 µm. c, ChAT and SmB immunostaining of L2 MNs from WT (SMNΔ7) mice and either AAV9-GFP (5) or AAV9-SMN (5) injected SMA mice at the indicated time points. Scale bar=10 µm. d, PV and SmB immunostaining of L2 PNs from the same groups as in (c). Scale bar=10 µm.
