Extended Data Fig. 1: Dynamics of putative pyramidal neurons in the basic task.
From: Attractor dynamics gate cortical information flow during decision-making
Hierarchical clustering of trial-averaged PSTHs of putative pyramidal cells recorded in vS1 (a, n = 256 cells) and ALM (b, left ALM n = 1648; right ALM n = 679 cells). a, Average spike rate of vS1 cells in each cluster and percentage of cells in each cluster. Red: trials without photostimulation, (lick-left). Blue: trials with photostimulation (lick-right); Cyan bar indicates the photostimulus. Top, correct trials. Bottom, error trials. Data is presented as trial-averaged activity, then averaged across cells belonging to each cluster ± s.e.m. (across cells, shaded). Cells in vS1 (clusters 1–4) did not switch selectivity on error trials, indicating that they tracked stimulus-related information. b, Same for ALM neurons. Neurons recorded from both hemispheres were clustered together. Bars show the percentage of putative pyramidal cells in left and right ALM that fall within each cluster, mean ± s.e.m across cells. Statistical significance was assessed by Wilcoxon rank sum test (two-sided). Cells in ALM often showed opposite selectivity on error trials (for example, Cluster 1–3), indicating that they tracked choice-related information. Despite the laterality of the movement, trial type selective preparatory activity was similar in left and right ALM (see distribution of cells in clusters 1–3 across hemispheres). Only a minority of cells in ALM did not switch selectivity on error trials – indicating sensory responses (for example, Cluster 4; note that cells in this cluster were more prevalent in left hemisphere). In addition, there was a cluster with neurons exhibiting non-selective ramping responses (Cluster 6), and a cluster with neurons responding to auditory cues that delineated the sample epoch (Cluster 10).
