Extended Data Fig. 5: Breakpoint analysis for food and water reward in hunger and thirst. | Nature Neuroscience

Extended Data Fig. 5: Breakpoint analysis for food and water reward in hunger and thirst.

From: Hunger or thirst state uncertainty is resolved by outcome evaluation in medial prefrontal cortex to guide decision-making

Extended Data Fig. 5: Breakpoint analysis for food and water reward in hunger and thirst.

a, Cumulative presses for food (green) and water (blue) for one example animal throughout one breakpoint session in hunger (left) and thirst (right) b, Total lever presses for water (blue) and food (green) in a group of mice switching between hunger and thirst (n = 7). c, Breakpoint ratio in hunger (green) and thirst (blue) for switching need state animals. d, Post-reinforcer pausing in seconds as a measure of motivation during the early, middle (mid), or late part of the breakpoint session for switching animals. e, Total lever presses for water (blue) and food (green) in switching and constant need state conditions with pre-exposure to food and water in home cage. f, Breakpoint ratio in hunger (green) and thirst (blue) for switching and constant need state animals with pre-exposure to food and water in home cage (n = 7 mice for each group in hunger and thirst). g, Breakpoint ratio for switching and constant animals in regular or pre-exposure conditions separately for hunger (left) and thirst (right). Thick lines represent mean. Error bars represent SEM. *P<0.05; ns, P>0.05. Detailed information about the exact test statistics, sidedness, and values are provided in Supplementary Table 1.

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