Extended Data Fig. 8: Tissue specificity exploration with permissive thresholds.

To determine whether our tissue-specificity results were biased by statistical power, we performed similar analyses with two more permissive p-values on the 411 proteins. a, Venn diagrams of all pQTLs across all three tissues by fixing genome-wide significance threshold (5 × 10^-8) for all three tissues. b, Venn diagrams of all pQTLs across all three tissues by fixing genome-wide significance threshold for one tissue and 0.001 for the other two tissues. For example, when checking CSF pQTLs shared in plasma or brain, we chose 5 × 10^-8 as threshold for CSF and 0.001 for plasma or brain. c, Venn diagrams of all pQTLs across all three tissues by fixing genome-wide significance threshold for one tissue and 0.05 for the other two tissues. For example, when checking CSF pQTLs shared in plasma or brain, we chose 5 × 10^-8 as threshold for CSF and 0.05 for plasma or brain.