Extended Data Fig. 8: The rebound of slow wave activity after sleep deprivation is specific to cortical areas but not layers.
Time course of NREM slow wave activity (SWA) after sleep deprivation (a) in the LFPs from layers 2/3 and 5 in primary motor cortex and (b) in the frontal and occipital EEG derivation. Note that cortical SNAP25-ablated animals (cKO) had lower initial SWA levels in the frontal EEG and LFP recordings across all layers, compared to controls (CTR). n = 5 CTR and n = 5 cKO for laminar analysis, n = 5 CTR and n = 8 cKO for EEG spectral analysis. Black asterisks indicate post-hoc contrasts with significant differences (*p < 0.05, **p < 0.01, ***p < 0.001). Data in panels a and b are presented as mean values ± SEM (shaded areas). See Supplementary Table 1 for detailed results. cKO: conditional knockout animals. CTR: control animals.
