Extended Data Fig. 9: Relative EEG power spectra during sleep deprivation show an attenuated increase in theta activity cortical SNAP25-ablated animals.
Wake EEG spectral power during the 6-hour sleep deprivation shown as a frequency bin-wise percentage of 24 h baseline values. Note that the expected increase in theta-power during sleep deprivation, which is visible in CTR mice, is severely diminished in cKOs. n = 5 CTR and n = 8 cKO for EEG spectral analysis. Individual asterisks indicate spectral bins with significant differences in post-hoc comparison before (grey) and after (black) Bonferroni adjustment of α. Data are presented as mean values ± SEM (shaded areas). See Supplementary Table 1 for detailed results. cKO: conditional knockout animals. CTR: control animals. EEG: electroencephalogram.
