Extended Data Fig. 9: Chemogenetic stimulation of RMTg GABA neurons does not alter sucrose preference in two-bottle choice test. | Nature Neuroscience

Extended Data Fig. 9: Chemogenetic stimulation of RMTg GABA neurons does not alter sucrose preference in two-bottle choice test.

From: Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior

Extended Data Fig. 9: Chemogenetic stimulation of RMTg GABA neurons does not alter sucrose preference in two-bottle choice test.

a-d. Chemogenetic activation of RMTg GABA cells does not alter preference for 60% or 5% sucrose or water consumption in two-bottle choice test. e. Sucrose consumption presented as percent change of baseline (5% sucrose (n (m-Cherry) = 6 rats, n (hM3Dq) = 7 rats) two tailed unpaired t test, * p = 0.0105; 60% sucrose (n (m-Cherry) = 6 rats, n (hM3Dq) = 7 rats) two tailed unpaired t test p = 0.0610). f. Representative coronal section of RMTg Gq DREADD expressing neurons. Blue – DAPI; Red – m-Cherry (Gq DREADD); Green – GAD 67 (GABA neurons). g. Spread of overlay of individual animal viral expression across RMTg in DREADD and control m-Cherry injected GAD-cre animals. The data are presented as the mean ± s.e.m. h-j. PPR is not correlated with the evoked amplitude of initial response at any inter-pulse interval. The data are presented as regression line and 95% confidence interval.

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