Extended Data Fig. 3: Intrinsic excitability of VTA DA neurons is decreased in CFA injected animals.
From: Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior
a. Action potential threshold is not altered in either by CFA or upon application of PTX (n (SAL) = 21 cells from 5 rats, n (CFA) = 23 cells from 4 rats). b. Application of picrotoxin (PTX) further depolarized cells from the CFA group while it has no effect on the cells from saline injected animals (one sample t test compared to 100 percent, CFA, **** p < 0.0001, n (SAL) = 21 cells from 5 rats, n (CFA) = 23 cells from 4 rats). c. Application of picrotoxin (PTX) decreases the amount of current required to depolarize cells to fire an action potential in CFA treated animals (one sample t test compared to 100 percent, CFA, ** p = 0.0031, n (SAL) = 20 cells from 5 rats, n (CFA) = 22 cells from 4 rats). d. PTX increased input resistance in CFA but not saline treated animals (one sample t test compared to 100 percent, CFA, * p = 0.0373, n (SAL) = 21 cells from 5 rats, n (CFA) = 23 cells from 4 rats). The data are presented as the mean ± s.e.m.
