Extended Data Fig. 3 | Nature Neuroscience

Extended Data Fig. 3

From: Integrating whole-genome sequencing with multi-omic data reveals the impact of structural variants on gene regulation in the human brain

Extended Data Fig. 3

Comparison between brain and monocytes SV-eQTLs effect sizes. Scatter plot shows the slope of 429 eGenes mapped in ROS/MAP DLPFC and Monocytes with a significant association in either dataset (FDR < 5%). Although majority of effects are concordant in direction, many genes show opposite direction of effects between brain and monocytes (for example ARL17B and CASP8). The x-axis shows the effect size in DLPFC and y-axis shows the effect size in Monocytes for the same SV-gene pair. Dots colored in blue are significant only at Monocytes, dots colored in grey are significant only in DLPFC, and dots in red are significant in both. Pearson correlation coefficient (and P-value, two-sided) of slopes for all 144 SV-gene pairs is shown on top.

Back to article page