Fig. 2: Enrichment of common SCZ risk variants in dysregulated peaks in NeuN⁺ and bulk tissue.

a, SCZ heritability coefficients of genetic variants overlapping histone peaks from Study-1 H3K27ac NeuN⁺, Study-2 H3K27ac Tissue and H3K27ac Meta NeuN⁺ stratified by (1) ‘ΔSCZ’: dysregulated peaks (n = 3,360, 5,656 and 6,219 peaks, respectively); (2) ‘ΔSCZ ↑ ’: hyper-acetylated dysregulated peaks (n = 1,918, 2,681 and 4,031 peaks, respectively); and (3) ‘ΔSCZ ↓ ’: hypo-acetylated dysregulated peaks (n = 1,442, 2,975 and 2,188 peaks, respectively) with log₂FC (SCZ versus controls) >0 and <0, respectively. Error bars represent standard error in SCZ heritability from LD score regression. b, Heat map of enrichment P values of brain-related GWAS traits. The overlap of peaks with genetic variants was assessed using LD score regression. ‘#’: significant for enrichment in LD score regression after FDR correction of multiple testing across all tests in the plot (Benjamini–Hochberg test); ‘*’: nominally significant for enrichment.