Extended Data Fig. 9: The effect of the optogenetic inhibition and excitation of dopaminergic terminals disappears with additional fear conditioning training.
From: Dopamine signaling in the nucleus accumbens core mediates latent inhibition
Freezing response to the CS+ and pre-exposed CS+ did not differ in the eYFP or ChR2 groups on the second session of fear conditioning (multiple comparison Ps > 0.05). Freezing to the CS+ was still greater than the freezing response to the pre-exposed CS+ at the end of the session 2 (two-way ANOVA cue × group interaction F(2,36) = 4.31, P = 0.02; multiple comparisons: NpHR pre-exposed CS+ versus CS+ P = 0.04). This suggest that the freezing response to all cues (pre-exposed and non-pre-exposed) reached the asymptotic level with additional training but the enhancing effect of dopamine inhibition during pre-exposure on latent inhibition persisted beyond the initial fear conditioning session. Data represented as mean ± s.e.m., * P < 0.05, ns = not significant.
