Extended Data Fig. 5: Silencing 4-7-week-old abDGCs preserves spatial information and coherence of CA3 and CA1 place maps but increases CA3-CA1 co-firing during spatial novelty.
From: Adult-born dentate granule cells promote hippocampal population sparsity
(a) Spatial rate maps from example CA3 and CA1 PCs (one cell per row) recorded from an abDGC::ArchT (4-7 wpi) mouse during laser-off and laser-on exploration sessions in the familiar and novel environments. The peak firing rate (Hz) is given above each map. (b,c) Silencing 4-7-week-old abDGCs during laser-on sessions did not affect the spatial coherence (b) or the spatial information (c) of CA3 or CA1 place maps (p > 0.09 for spatial coherence; p > 0.25 for spatial information, two-sided permutation tests; DG = 49, CA3 = 36, CA1 = 126 cells in 4 mice). (d) Silencing abDGCs significantly increased temporal correlation of theta-nested spike trains in pairs of CA3 and CA1 PCs. However, note that this abDGC silencing effect on CA3-CA1 ensemble co-firing was seen during novel environment exploration (p = 0.4 for familiar, p = 0.03 for novel, two-sided paired permutation tests; n = 4087 CA3-CA1 cell-pairs in 3 mice). Panels b-d show Cumming estimation plots as described in Extended Data Fig. 1e. *p < 0.05.
