Extended Data Fig. 8: Rescue of synaptic integrity in PS19 after bassoon downregulation.
From: Bassoon contributes to tau-seed propagation and neurotoxicity
a, Pearson’s correlation of PSD95 and Syn-1 in WTscramble, WTshBSN, PS19scramble, and PS19shBSN mice, separated by sex. b, Representative immunofluorescence in scramble and shBSN PS19 mice for misfolded tau (MC1), and Syn-1 protein. Colocalization analysis was performed to determine pixel intensity correlation between MC1 and Syn-1. Scale bar: 50 µm for main panels and 10 µm for insets. c, Pearson’s correlation of MC1 and Syn-1 immunostainings in scramble and shBSN PS19 mice. Data are shown as the mean ± s.e.m. Experiments were performed with n = 4 per sex (a), and n = 8 (b, c). Significance was determined by one-way ANOVA (a), and unpaired two-tailed Student’s t-test (c).
