Extended Data Fig. 10: Downregulation of bassoon corresponds to reduced ventricular volume and an increment of hippocampal volume in PS19 mice.
From: Bassoon contributes to tau-seed propagation and neurotoxicity
a–c, In vivo Magnetic resonance imaging (MRI) (a), quantification of ventricular (b), and hippocampal volume normalized to total brain volume (c), in 9-month-old WT and PS19 mice injected with shBSN or scramble shRNA. Data represent the mean ± s.e.m. Experiments were performed with n = 7 for WTscramble, n = 8 for PS19scramble, n = 4 for WTshBSN, and n = 7 for PS19shBSN mice. Significance was determined by one-way ANOVA (b, c). b, c, for box plots, midlines represent the median, boundaries are interquartile range, and the whiskers are minimum-maximum.
