Fig. 6: Bassoon downregulation restores electrophysiological impairments in PS19 mice.
From: Bassoon contributes to tau-seed propagation and neurotoxicity
a, Superimposed fEPSP traces produced by stimulation of the Schaffer collateral pathway and recorded in CA1 brain slices before (gray dashed lines) and after (gray, orange, black and light blue lines) LTP induction. Vertical bar, 300 mV; horizontal bar, 10 ms. b–d, Summary of in vivo LTP (b), averaged from minute 60 to 70 (c), and PPR (d), in 6-month-old WT and PS19 mice injected with shBSN or scramble shRNA. Data represent the mean ± s.e.m. Experiments were performed with n = 11 for WTscramble, n = 11 for PS19scramble, n = 10 for WTshBSN and n = 11 for PS19shBSN mice (b–d). Significance was determined by two-way ANOVA (c and d).
