Extended Data Fig. 9: Morphological analysis of microglia in intact and injured brains. | Nature Neuroscience

Extended Data Fig. 9: Morphological analysis of microglia in intact and injured brains.

From: TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury

Extended Data Fig. 9

a, Representative images of 4C4+ microglia in Wt (grna+/+;grnb+/+) or Grn-deficient (grna−/−;grnb−/−) intact, injured (7 dpi), and phase-separated TDP-43- or FUS-injected (grna+/+;grnb+/+) brains. Scale bars, 20 µm. b–d, Violin plots depicting the number of main processes (b), area of somata (c) and average process length (d) of 4C4+ microglia in telencephalic parenchyma of Wt (grna+/+;grnb+/+) or Grn-deficient (grna−/−;grnb−/−) intact, injured and TDP-43- or FUS-injected (grna+/+;grnb+/+) brains. Group sizes are indicated in the violin plots. Each point represents one cell. Significance was calculated with Kruskal-Wallis test, with post-hoc Dunn’s test for multiple comparisons.

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