Extended Data Fig. 1: Coding of visual vs. auditory stimuli in visual cortex and hippocampal formation.
From: Behavioral origin of sound-evoked activity in mouse visual cortex
a. Time courses of the auditory PC1 averaged across mice (z-scored), measured in visual cortex (VIS, top) and hippocampal formation (HPF, bottom). Traces show the actual data (purple) and the cross-validated prediction from the behavioral model (black). b. Same as a, but for visual PC1 (green). c. Reliability of each auditory (left) or visual (right) PC, in VIS (top, n = 8 mice) or HPF (bottom, n = 5 mice). The large dot shows the z-transformed mean; the bounds of each box show the 25th and 75th percentiles; the whiskers show the minimum and maximum values that are not outliers; small dots show outliers (computed using the interquartile range); individual dots are also shown. d. Decoding accuracy of sound identity from auditory PCs (left) or video identity from visual PCs (right) measured in VIS, taking the full subspace or the full subspace except PC1. Sound decoding was significantly worse without auditory PC1 (*: p = 0.0156, two-sided paired Wilcoxon sign rank, n = 8 mice). e. Same as c but showing the similarity across animals. Reliability of each PC is shown for reference (gray, replotted from c). f. Similarity of visual and auditory PCs between VIS and HPF. g. Same as e, for the predictability of each PC by the behavioral model, measured by the cross-validated correlation between data and model prediction. The model can sometimes predict the test set better than the train set because it can predict fluctuations specific to the test set.
