Extended Data Fig. 10: Zero-order protein-protein interaction (PPI) networks for genes associated with multiple subgroups.
From: Molecular and network-level mechanisms explaining individual differences in autism spectrum disorder
Zero-order protein-protein interaction (PPI) networks for (a) genes associated with all four subgroups and (b) genes associated with at least 3 subgroups (STRING database; see Methods). Blue genes are known to be transcriptionally regulated in ASD while red genes are genes not known to be transcriptionally regulated but that have been associated with ASD in the SFARI database. The significance of each PPI module is the two-sample Wilcoxon rank sum test (unpaired, two-sided) of within-module degrees versus cross-module degrees (no adjustments for multiple comparisons of modules). For each gene in the module, the within-module degree is the number of connected genes within the module and the cross-module degree is the number of connected genes outside of the module.
