Extended Data Fig. 9: AppNL-G-F mice have an increased susceptibility to develop seizures. | Nature Neuroscience

Extended Data Fig. 9: AppNL-G-F mice have an increased susceptibility to develop seizures.

From: Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease

Extended Data Fig. 9: AppNL-G-F mice have an increased susceptibility to develop seizures.

a,b,c, Time taken by Wt and AppNL-G-F mice to reach seizure level score (see method section) in response to i.p. injection of PTZ (40 mg/kg) at (a) B state (beginning of light phase) (stage 4: Wt vs AppNL-G-F p = 0.035, stage 5: Wt vs AppNL-G-F p = 0.0008) and (b) SD (stage 4: Wt vs AppNL-G-F p = 0.0003, stage 5: Wt vs AppNL-G-F p = 0.0001) and (c) after RB sleep (stage 3: Wt vs AppNL-G-F p = 0.0001, stage 4: Wt vs AppNL-G-F p = 0.0001, stage 5: Wt vs AppNL-G-F p = 0.0001). Number of mice: 6 MO - B: Wt n = 10, AppNL-G-F n = 11; SD: Wt n = 8, AppNL-G-F n = 10; RB: Wt n = 9, AppNL-G-F n = 10. Two-way ANOVA, with Holm-Sidak post-hoc multiple comparisons test. Individual data points shown with bars representing mean ± SEM. (*p < 0.05, **p < 0.01, ***p < 0.001). d, Mean score of seizure reached by Wt and AppNL-G-F mice in response to i.p. injection of PTZ (40 mg/kg) at B, SD and RB sleep. Number of mice: 6 MO - B: Wt n = 10, AppNL-G-F n = 11; SD: Wt n = 8, AppNL-G-F n = 10; RB: Wt n = 9, AppNL-G-F n = 10 (p = 0.0117). One-way ANOVA with Tukey’s post-hoc test. Individual data points shown with bars representing mean ± SEM. (*p < 0.05).

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