Extended Data Fig. 5: Functional enrichment of adDEGs.
From: Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer’s disease
a. Heatmap showing the significance of GO term overlap between adDEG sets. The -log10(adj.p-value) by Fisher’s exact test represents the significance (adj.p-value < 0.05 as a cutoff). b. Top enriched Gene Ontology biological processes in up-regulated adDEGs (left) and down-regulated adDEGs (right). Enrichr in R was used to perform GO enrichment (proportion test, adjusted p-value < 0.05 as cutoff, one-sided). The full list of enriched GO terms is shown in Supplementary Table 7.
