Fig. 8: A proposed mechanistic model for the formation of seeding competent TDP-43 fibrils.
From: Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage
Schematic of the mechanisms of TDP-43 filament formation, and potential pathways that could lead to the generation of seeding competent cleaved fibrils with exposed amyloid cores.
