Extended Data Fig. 1: Amyloid dyes bind weakly to FL TDP-43 filaments.
From: Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage
a, b, and c) Chemical structures of ThT (a), ThS (b), and CR (c) molecules. d) ThT fluorescence spectra of total TDP-43 filaments after 5 days and resuspended pelleted TDP-43 filaments following isolation protocol. e) ThS fluorescence spectra of pelleted TDP-43 filaments and tau fibrils. f) CR absorbance spectra of pelleted TDP-43 filaments, αSyn fibrils, and CR in buffer alone.
