Extended Data Fig. 2: DHPG-LTD is not abolished in α-Syn-KO and βγ-Syn-KO mice.
From: Postsynaptic synucleins mediate endocannabinoid signaling
a-d, eCB-LTD in α-Syn-KO (WT data from Fig. 1: n = 11 cells / 4 mice, 69.95 ± 1.70%; α-Syn-KO: n = 10 cells / 4 mice, 83.44 ± 4.67%; p = 0.162). b, eCB-LTD in βγ-Syn-KO mice (n = 11 cells / 5 mice, 71.00 ± 3.38%; p = 0.957). c, Summary of EPSC amplitudes. d, Summary of PPRs in α-Syn-KO (baseline: 1.03 ± 0.05; post-DHPG: 1.10 ± 0.06; p = 0.037) and βγ-Syn-KO mice (baseline: 0.98 ± 0.06; post-DHPG: 1.05 ± 0.05; p = 9.8e-3). Data are mean ± SEM. (c, d) Box plots are depicted as mean (center), first/third quartile (lower/upper box limits), and minima/maxima (bottom/top whiskers). Statistical significance was assessed by two-sided tests, including ANOVA with multiple comparisons (c), and Wilcoxon signed tests (d) (**** p < 0.0001; ** p < 0.01; * p < 0.05; n.s. non-significant).
