Extended Data Fig. 6: B2m deficiency alters learning and memory-related transcriptional profiles in oAβ-injected mice. | Nature Neuroscience

Extended Data Fig. 6: B2m deficiency alters learning and memory-related transcriptional profiles in oAβ-injected mice.

From: β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice

Extended Data Fig. 6: B2m deficiency alters learning and memory-related transcriptional profiles in oAβ-injected mice.The alternative text for this image may have been generated using AI.

a, Schematic of oAβ injection and RNAseq analysis. Two- to three-month-old WT and B2m−/− mice were ICV injected with oligomeric Aβ42 (oAβ) or PBS (Vehicle). Hippocampal tissues were dissected, and total RNA was isolated, purified and sequenced. n = 3 mice per group. b, Volcano plots with genes that were significantly downregulated (blue) or upregulated (red) in the hippocampus of oAβ-injected 2- to 3-month-old B2m−/− versus WT mice (fold change > 1.5, P value < 0.05) (two-tailed Wald test). c, GO analysis of upregulated genes in the oAβ-injected B2m−/− mouse hippocampus (hypergeometric test, qvalueCutoff = 0.05). d, GO analysis of downregulated genes in the oAβ-injected B2m−/− mouse hippocampus (hypergeometric test, qvalueCutoff = 0.05). e, Heatmap depicting upregulated genes in the oAβ-injected B2m−/− mouse hippocampus.

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