Extended Data Fig. 5: Pre-ranked gene set enrichment analysis (GSEA) of the hippocampal proteomics. | Nature Neuroscience

Extended Data Fig. 5: Pre-ranked gene set enrichment analysis (GSEA) of the hippocampal proteomics.

From: Heart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2

Extended Data Fig. 5

Dot plots show: a) Top 20 up- and top 20 down-regulated GO biological process, b) top 10 up- and top 20 down-regulated GO cellular component, c) top 10 up- and top 20 down-regulated GO molecular function terms. Significantly changed protein abundance was determined by unpaired t-test with a threshold for significance of p < 0.05 (permutation-based FDR correction), fold-change ≥1.5, unique peptides ≥2. Data are derived from biologically independent samples. All statistical tests were two-sided.Source file PRIDE #PXD042295.

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