Extended Data Fig. 6: Gene set enrichment analysis (GSEA) of the hippocampal proteomics.

The enrichment plots of representative KEGG pathway gene sets demonstrate that oxidative phosphorylation (a), Parkinson’s disease (b), Alzheimer’s disease (c), and Huntington’s disease (d) are significantly enriched in MI compared to SHAM. The heatmap on the right side of each panel visualizes the genes contributing to the enriched pathways. For the detailed list see Supplementary Table 8. Signal-to-noise ratio was used to rank the genes per their correlation with either MI phenotype (red) or SHAM phenotype (blue). The y-axis represents enrichment score (ES) and on the x-axis are genes (vertical black lines) represented in gene sets. The GSEA analysis calculates an enrichment score (the maximum deviation from zero) reflecting the degree of over-representation of a gene set at the top or the bottom of the ranked gene list. A positive ES indicates gene set enrichment at the top of the ranked list; a negative ES indicates gene set enrichment at the bottom of the ranked list. NES, normalized enrichment score; FDR, FDR adjusted p-value.