Fig. 2: Motor learning refines direction coding through the suppression of irrelevant activity.
From: An adaptive behavioral control motif mediated by cortical axo-axonic inhibition
a, Schematic of MD. An average pixel-based activity map of MD (top, n = 6 mice). Color-coded map of PDs of direction-tuned neurons (bottom, von Mises fitting, P value of correlation coefficients, P < 0.05, and DSI ≥ 0.4), colored according to their PD. Non-direction-tuned neurons (P ≥ 0.05 or DSI < 0.4) are shown in gray. b, Example heat map of premotor neurons’ tuning for MD in early learning (session 1, top) and late learning (session 7, bottom). Data are sorted from the location of peak likelihood probability P(active|MD). Corresponding precisions of population responses for each MD (right). c, Changes of average precision curves of population responses. d, Comparison of population response precisions (n = 6 mice for the experimental group, two-tailed paired t-test, t = −4.98, P = 0.0042; n = 5 mice for the control group, t = 2.56, P = 0.063). e, Normalized percentage of active cells in the population as a function of distance from the PD (n = 830 cells for early, n = 937 cells for late in the experimental group; n = 705 cells for early, n = 671 cells for late in the control group). f, Changes in the percentage of active cells (two-tailed Student’s t-test, t = 5.149, P = 0.0036 for the experimental group; t = 0.106, P = 0.920 for the control group). g, Movement speed (top), posterior probabilities (middle) and corresponding actual and decoded MD estimated with MAP (bottom). h, Changes in posterior probabilities, P(MD|active), normalized by chance level (dashed line) as a function of distance from MD with learning. i, Probability distributions of decoding error. j, Pairwise correlations with respect to ΔPD normalized by early session 1 (angular difference in PD between neuronal pairs, n = 58,456 pairs for session 1, n = 67,143 pairs for session 7 for the experimental group; n = 51,285 pairs for session 1, n = 45,156 pairs for session 7 for the control group). **P < 0.01; error bars and shading indicate s.e.m. Exp, experimental.
