Extended Data Fig. 10: D1R-targeted drug effects on D1-/D2-SPN Ca2+ dynamics as a function of locomotor speed under normal and hyperdopaminergic conditions.
a, b, Drug effects on D1- (a) and D2-SPN (b) Ca2+ event rates across different speed bins following vehicle or drug only treatment. c, d, Drug effects on the proximal co-activity of D1- (c) and D2-SPNs (d) across different speed bins following vehicle or drug only treatment. e, f, Drug effects on Ca2+ event rates of D1- (e) and D2-SPNs (f) across different speed bins following vehicle or drug + amphetamine treatment. g, h, Drug effects on the proximal co-activity of D1- (g) and D2-SPNs (h) across different speed bins following vehicle or drug + amphetamine treatment. Data are represented as mean ± s.e.m. (****P < 10−4, ***P < 10−3, **P < 10−2 and *P < 0.05 for comparison to vehicle treatment (a–d) or to vehicle + amphetamine treatment (e–h); Two-way ANOVA with Holm-Sidak’s multiple comparison test).
