Extended Data Fig. 10: Suppressing MPOA Vgat neurons in male mice, local administration of estrogen in MPOA and local administration of an estrogen receptor antagonist in MPOA. | Nature Neuroscience

Extended Data Fig. 10: Suppressing MPOA Vgat neurons in male mice, local administration of estrogen in MPOA and local administration of an estrogen receptor antagonist in MPOA.

From: The medial preoptic area mediates depressive-like behaviors induced by ovarian hormone withdrawal through distinct GABAergic projections

Extended Data Fig. 10

a-h, Local administration of estradiol (E2) (or vehicle) in MPOA following the HW procedure in female mice. N = 8 animals for each group. Mean ± s.d. Statistics: ***P = 0.0002 (b), ****P < 0.0001 (c), ****P < 0.0001 (d), **P = 0.0011 (e), ***P = 0.0004 (f), ***P = 0.0005 (g), ****P < 0.0001 (h), two-tailed Mann-Whitney test, n = 9 mice in each group. i-p, I.p. administration of estradiol (E2) and local administration of estrogen receptor antagonist (ICI 182,780) (or vehicle) in MPOA following the HW procedure in female mice. n = 9 mice in each group, mean ± s.d. Statistics: **P = 0.0097 (j), *P = 0.0379 (k), *P = 0.0362 (l), ***P = 0.0009 (m), *P = 0.0101 (n), **P = 0.0068 (o), ***P = 0.0002 (p), two-tailed Mann-Whitney test.

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