Extended Data Fig. 10: Highly correlated signaling in axons and somas within genetic subtypes of dopamine neurons.
From: Unique functional responses differentially map onto genetic subtypes of dopamine neurons
(a) Example recording for Aldh1a1 showing simultaneous fluorescence traces (ΔF/F) from SNc and striatum. Isosbestic control shown in blue. ▼= Example transients present in SNc and in striatum. (b) Cross-correlation between ΔF/F traces from striatum and SNc shown in A. Isosbestic control shown in blue. (c) Average cross-correlation between ΔF/F traces from striatum and SNc for all recordings of Aldh1a1 (as Fig. 6e). Isosbestic control shown in blue. Shaded regions denote mean ± s.e.m. Heatmap shows cross correlations for each paired recording sorted by peak magnitude. Aldh1a1 mice = 8, n = 29 recordings. (d) Distribution of peak cross correlations between SNc and striatum for recordings of Aldh1a1 and DAT shown in C (as Fig. 6f). P-value for comparison DAT-Aldh1a1 = 0.03 (two-sided Mann-Whitney U test with Bonferroni correction). (e) Peak cross correlations between dorsal striatum recordings (from Aldh1a1 or DAT) vs different relative depths in SNc, showing that for Aldh1a1 dorsal striatum signaling is best correlated to ventral SNc.
