Extended Data Fig. 5: Electrophysiology supporting data 2.
From: Orbitofrontal cortex control of striatum leads economic decision-making
a. Chosen-side classification accuracy of 4-fold cross validated support vector machine trained on single unit activity recorded in either the OFC (blue) or DMS (red) on correct trials, and tested on either held-out correct trials (left) or incorrect trials (center). Note decoding performance is reduced compared to Fig. 3 due to the relatively small number of incorrect trials performed. Right, classification accuracy reaches equivalent levels on both correct and incorrect trials in both the OFC and DMS (n = 20 random samples, two-way repeated-measures ANOVA). b. Average predicted choice parameters computed on single correct (left) or incorrect (right) trials aligned to choice response (n = 30 sessions). c. Peak predicted choice parameters are equivalent on correct and incorrect trials (n = 20 random samples, two-way repeated-measures ANOVA). d. Latency to predicted choice parameter threshold relative to choice on correct or incorrect choice trials for models trained using data recorded simultaneously from OFC (blues) or DMS (reds). OFC activity does not precede DMS activity when animals make incorrect choices (n = 20 random samples, two-way repeated-measures ANOVA). * P < 0.05, ** P < 0.01, *** P < 0.001, Data are presented as mean ± SEM.
