Table 1 Capability of IL-12 sensing in bone marrow chimera mice

From: IL-12 sensing in neurons induces neuroprotective CNS tissue adaptation and attenuates neuroinflammation in mice

 

Il12rb2del → Il12rb2del

Il12rb2fl → Il12rb2del

Il12rb2del → Il12rb2fl

Il12rb2fl → Il12rb2fl

Peripheral and CNS-invading leukocytes

−

+

−

+

CNS tissue-resident cells (neuroectoderm, microglia and TRM cells)

−

−

+

+

EAE outcome

Hyperinflamed

Hyperinflamed

Normal

Normal

  1. +, IL-12 responsive, −, IL-12 unresponsive.
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