Extended Data Fig. 8: Role of the PPC in re-categorisation and the risky-choice task.
From: The rat frontal orienting field dynamically encodes value for economic decisions under risk
a. Behavioral adaptation of subjects 2153, 2154, 2156 and 2160 in the surebet learning experiment. For each animal, we fit a model to the control trials and used it for predicting the shifts. Top three subpanels: the circles with error bars are the binned mean and 95% binomial confidence intervals; the ribbons are generated using the fit parameter posterior of with 80% confidence intervals. behavior from 6 sessions immediately before a surebet change is in gray, behavior from 7 sessions after a surebet change (including the very day) is in light blue if no infusion, in gold if with 0.6 μg bilateral PPC infusion. Text annotation shows the old and new surebet magnitudes. Bottom subpanel: The chose lottery % of each session. Asterisk indicates when change in choices can be significantly detected on that session compared to the previous 6 sessions with old surebet magnitude. b. The psychometric plots are versions of Fig. 2b,e,h but using only the first 40 trials in each session. The rightmost plot show the p-value of the infusion from GLMM model as a function of the the cut-off for including trials as ‘early’. The behavioral effect of PPC silencing on risky choice lasted only about 45 trials. Including more then 45 trials begins to wash out the effect and after 80 trials there is no longer a significant effect (n = 7 rats, the circles with error bars are the mean and 95% binomial confidence intervals, z-test, two-sided, not adjusting for multiple comparisons.). c. 3-agent fits to the fits 40 trials of PPC muscimol sessions. The model suggests that the effect of PPC silencing is on the bias parameters, particular a decrease in ωlottery and increase in ωsurebet. This can be seen in the psychometric plot from 2156 (left panel, n = 40 trials, the circles with error bars are the binned mean and 95% binomial confidence intervals, the dark and light shade represent model predicted 50%, 80% confidence intervals.). The change due to PPC silencing appears to be a downward shift (n = 7 rats, a star (*) indicates that 97.5% of the posterior was not overlapping with 0).
