Extended Data Fig. 5: Female Mef2c L35P+/- mice displayed abnormal social novelty ability and object recognition.
From: Whole-brain in vivo base editing reverses behavioral changes in Mef2c-mutant mice
(a) Representative heat maps for locomotion of female Mef2c WT and L35P+/- mice on the social approach and social novelty session in the three-chamber test. Quantification of cumulative duration of interacting with a mouse and empty cage of Mef2c WT (b) and L35P+/- mice (c) (n = 8, b: P < 0.0001; c: P = 0.0024). (d) The preference index of social approach test for female Mef2c WT and L35P+/- mice. Quantification of cumulative duration of interacting with novel stranger mouse and familiar mouse of female Mef2c WT (e) and L35P+/- (f) mice (n = 8, e: P = 0.0002). (g) The preference index of social novelty test for female Mef2c WT and L35P+/- mice. (P = 0.046) (h) Representative heat maps of female Mef2c WT and L35P+/- mice in the novel object recognition task (the circle indicates a familiar object; the white box indicates a stranger object). Quantification of cumulative sniffing time of Mef2c WT (i) and L35P+/- mice (j) in the task (n = 8, i: P = 0.0095; j: P = 0.163). n represents mice number. Statistical values represent the mean ± s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, (b, c, e, f, i, j) paired two-tailed Student’s t-test, (d, g) unpaired two-tailed Student’s t-test.
