Fig. 2: Heat map of the correlation between brain volumes and cognitive scores.

a,b, Correlation assessed between the predicted values for brain volumes and cognitive and motor scores at age 2 using Pearson’s correlations in children born full term (a) and preterm (b). In full-term children, the significant correlations are ICV–gross motor score (P = 0.0000), amygdala–gross motor score (P = 0.001), ICV–fine motor score (P = 0.0002), caudate–visual reception score (P = 0.001) and globus pallidus–visual reception score (P = 0.0005). In preterm children, the significant correlation is hippocampus–visual reception score (P = 0.0007). Brain volume–cognitive score correlations are highlighted in the dashed rectangle. The squares marked with an asterisk (*) represent significant correlations (P < 0.0015, which is the threshold for significance after Bonferroni correction for multiple comparisons). Data were analyzed by two-tailed t-tests; TLM, thalamus; CDT, caudate; PTM, putamen; PLD, globus pallidus; HPS, hippocampus; AGD, amygdala; GM, gross motor score; VR, visual reception score; FM, fine motor score; RL, receptive language score; EL, expressive language score.