Extended Data Fig. 9: Comparable basal diameter of p-arterioles between littermate control and aSMC-cKOGrin1 mice. | Nature Neuroscience

Extended Data Fig. 9: Comparable basal diameter of p-arterioles between littermate control and aSMC-cKOGrin1 mice.

From: Synaptic-like transmission between neural axons and arteriolar smooth muscle cells drives cerebral neurovascular coupling

Extended Data Fig. 9: Comparable basal diameter of p-arterioles between littermate control and aSMC-cKOGrin1 mice.

(a) Side view of three-dimensional volume image of a two-photon-imaged site in SMACreER:Ai47 mouse barrel cortex. The lumen of all vessels is filled with i.v. injected rhodamine and aSMCs are genetically labeled by EGFP. The deepest imaged bin is at 300 μm. White slices correspond to z cross-sections shown per depth. (b-c) The baseline of basal diameter and blood flow. Tamoxifen was given to adult mice three weeks before cranial surgery, and live imaging was performed one week after cranial surgery in panels b and c. Independent replicates for a were conducted in 3 pairs of littermate control and aSMC-cKOGrin1 mice, n = 10 arterioles per group. Data are mean ± s.e.m.; nested, unpaired, two-tailed t-test (b, c).

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