Extended Data Fig. 10: Tuning down ACC–VTA–ACC feedback loop relieves hypersensitivity of thermal pain. | Nature Neuroscience

Extended Data Fig. 10: Tuning down ACC–VTA–ACC feedback loop relieves hypersensitivity of thermal pain.

From: An ACC–VTA–ACC positive-feedback loop mediates the persistence of neuropathic pain and emotional consequences

Extended Data Fig. 10: Tuning down ACC–VTA–ACC feedback loop relieves hypersensitivity of thermal pain.The alt text for this image may have been generated using AI.

a, Statistics of thermal pain behaviors of SNI (nerve ligation removing) (n = 8 mice) vs sham (n = 7 mice), hM4Di vs control virus-injected (in the VTA) SNI mice (with nerve ligation removed), and hM3Dq vs control virus-injected (in the ACC) SNI mice (with nerve ligation removed) 3 weeks after repetitive CNO application (every second day for 2 weeks, n = 6 mice for each). b, Schematic of quinpirole local administration in the ACC (1 µg/µl, 200 nl) of SNI mice. c, Statistics of thermal pain behaviors of SNI mice following the local application of quinpirole vs saline (n = 7 mice for each). d, e, As in (b, c), except that haloperidol (50 µM, 200 nl) was applied in the VTA (saline, n = 7 mice; haloperidol, n = 8 mice). The data are presented as the mean ± s.e.m. Unpaired Student’s t-test, *P < 0.05, **P < 0.01. Detailed statistics information can be found in the Source Data.

Source data

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