Extended Data Fig. 6: Controlling sleep/wake state classifier by removing marker genes between subtypes of KC or glia. | Nature Neuroscience

Extended Data Fig. 6: Controlling sleep/wake state classifier by removing marker genes between subtypes of KC or glia.

From: Single-cell transcriptomics reveals that glial cells integrate homeostatic and circadian processes to drive sleep–wake cycles

Extended Data Fig. 6

a, b. Glial and KC subtypes move closer to each other in a UMAP space, because marker genes above certain log foldchange thresholds are removed. Genes falling below a threshold of 3.5 or 2 for glia and KC, respectively were excluded for training the tree-based EBM classifier. c, d. Assigning the sleep or wakefulness label randomly results in random performance of the classifier for the same cell subtype.

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