Extended Data Fig. 5: Hebbian and non-Hebbian forms of excitatory synaptic plasticity are critical for memory encoding and consolidation.
From: Dynamic and selective engrams emerge with memory consolidation
a-b, Simulation protocol as in Fig. 1b but with blocked triplet STDP (that is, A = Bi(t) = 0, see Methods). a, Memory recall as a function of consolidation time. Means and 99% confidence intervals are shown. n = 10 trials. Color denotes stimulus as in Fig. 1c. b, Mean weight strength of plastic synapses clustered according to engram cell status. Top, feedforward excitatory synapses onto excitatory neurons. Middle, recurrent excitatory synapses onto excitatory neurons. Bottom, recurrent inhibitory synapses onto excitatory neurons. Left, at the end of the training phase. Right, after 24 h of consolidation. Representative trial is shown. c-d, Same as a-b but with blocked heterosynaptic plasticity (that is, β = 0, see Methods). e-f, Same as a-b but with blocked transmitter-induced plasticity (that is, δ = 0, see Methods).
