Fig. 2: Training-activated engram cells remain necessary and sufficient for memory recall.
From: Dynamic and selective engrams emerge with memory consolidation
Analysis of memory recall when training-activated engram cells in Fig. 1b are manipulated. Means and standard deviations are shown. n = 10 trials. a, Analysis of memory recall after 24 h of consolidation when training-activated engram cells are blocked during recall with cues of the training stimulus in the protocol in Fig. 1b. Left, firing rate of engram cells averaged across all cue presentations during recall (dashed line indicates threshold ζthr = 10 Hz for engram cell activation). Right, memory recall. b, Analysis of memory recall after 24 h of consolidation when training-activated engram cells are artificially reactivated during recall without any stimulus cues in the protocol in Fig. 1b. Left, firing rate of engram cells averaged across all reactivation intervals during recall (dashed line indicates threshold ζthr = 10 Hz for engram cell activation). Right, memory recall (note that standard deviation = 0 as recall = 100% in all trials).
