Fig. 4: Dynamic engrams underlie the emergence of memory selectivity.
From: Dynamic and selective engrams emerge with memory consolidation
a, Top, schematic (left) and representative image (right) of experimental mice. Bottom, schematic of experimental protocol. Representative image of a group of three independent samples. b, Freezing levels during fear training and memory recall. Freezing during recall in the neutral context and the training context shown for different delay times in the protocol in a. c, Average ΔF/F signal of engram cells during each session of the protocol in a. From left to right: dynamic engram, stable engram and random neurons. Experimental data: longitudinal ΔF/F calcium signals of imaged neurons, thus providing a proxy measure of their in vivo neural activity. Color denotes individual mouse as in b. Means and 95% confidence intervals are shown. d, Correlation between freezing discrimination and engram discrimination at different delay times. From left to right: dynamic engram, stable engram and random neurons. Discrimination indices were computed based on either the animal’s freezing levels or the average ΔF/F signals of engram cells during recall in the training and the neutral contexts (Methods). Color denotes individual mouse as in b. Spearman’s rank correlation coefficient and associated two-sided test with P are shown.
