Extended Data Fig. 1: Additional behavioral characterization of global knockout ASD models. | Nature Neuroscience

Extended Data Fig. 1: Additional behavioral characterization of global knockout ASD models.

From: The developmental timing of spinal touch processing alterations predicts behavioral changes in genetic mouse models of autism spectrum disorders

Extended Data Fig. 1

Related to Fig. 1. a, Distance traveled in the open field. n = 22 Gabrb3+/+ mice and n = 19 Gabrb3+/- mice, P = 0.7133; n = 15 Mecp2+/y mice and n = 8 Mecp2-/y mice, P = 0.0011; n = 14 Rorb+/+ mice and n = 18 Rorbh1/+ mice, P = 0.9394, unpaired two-tailed t-tests. n = 23 Nlgn2+/+ mice, n = 30 Nlgn2+/- mice, n = 14 Nlgn2-/- mice, P = 0.9832 for Nlgn2+/+ vs. Nlgn2+/-, P = 0.9755 for Nlgn2+/+ vs. Nlgn2-/-, one-way ANOVA with post hoc Dunnett’s tests. b, c, Discrimination indices for textured NORT assay, n = 13 Nlgn2+/+ mice and n = 19 Nlgn2+/- mice, P = 0.0376 (b) and shape/color NORT assay, n = 10 Nlgn2+/+ mice and n = 21 Nlgn2+/- mice, P = 0.9729 (c), with a positive value indicating a preference for a novel object versus a familiar object. Statistical analyses were performed using unpaired two-tailed t-tests. d, Fraction of time spent in the center of the open field chamber. n = 23 Nlgn2+/+ mice, n = 30 Nlgn2+/- mice, n = 14 Nlgn2-/- mice, P = 0.3289 for Nlgn2+/+ vs. Nlgn2+/-, P = 0.0020 for Nlgn2+/+ vs. Nlgn2-/-, one-way ANOVA with post hoc Dunnett’s tests. e, Fraction of time spent in the open arms of the elevated plus maze. n = 17 Nlgn2+/+ mice, n = 31 Nlgn2+/- mice, n = 12 Nlgn2-/- mice, P = 0.6302 for Nlgn2+/+ vs. Nlgn2+/-, P = 0.6886 for Nlgn2+/+ vs. Nlgn2-/-, one-way ANOVA with post hoc Dunnett’s tests. n = 14 Rorb+/+ mice and n = 18 Rorbh1/+ mice, P = 0.4630 for Rorb, unpaired two-tailed t-test. f, Tactile PPI. n = 15 Nlgn4+/+ mice, n = 9 Nlgn4+/- mice, n = 13 Nlgn4-/- mice, P = 0.8054 for Nlgn4+/+ vs. Nlgn4+/-, P = 0.8032 for Nlgn4+/+ vs. Nlgn4-/-. g, Response to a 0.9 PSI air puff stimulus alone. n = 15 Nlgn4+/+ mice, n = 9 Nlgn4+/- mice, n = 13 Nlgn4-/- mice, P = 0.8100 for Nlgn4+/+ vs. Nlgn4+/-, P = 0.6223 for Nlgn4+/+ vs. Nlgn4-/-. h, Fraction of time spent in the center of the open field chamber. n = 16 Nlgn4+/+ mice, n = 9 Nlgn4+/- mice, n = 15 Nlgn4-/- mice, P = 0.1075 for Nlgn4+/+ vs. Nlgn4+/-, P = 0.8535 for Nlgn4+/+ vs. Nlgn4-/-. i, Distance traveled in the open field. n = 16 Nlgn4+/+ mice, n = 9 Nlgn4+/- mice, n = 15 Nlgn4-/- mice, P = 0.9058 for Nlgn4+/+ vs. Nlgn4+/-, P = 0.8561 for Nlgn4+/+ vs. Nlgn4-/-. For a-i, data represent means ± s.e.m. For f-i, statistical analyses were performed using one-way ANOVAs with post hoc Dunnett’s tests. Statistical information provided in Supplementary Table 1.

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