Extended Data Fig. 3: Longitudinal changes in serum analytes.

a) Volcano plot of differentially expressed analytes between sample 1 (T1) and sample 2 (T2) following deterioration of clinical symptoms in hospitalised patients. b) Levels of sVCAM1, PAI-1, sICAM-1, IL-4, IL-13 and IL-8 between T1 and T2 (n = 27 paired samples). Error bars are mean ± s.d. For IL-8, ICAM-1, VCAM-1, PAI-1, VEGF, BDNF (n = 34 paired samples). Matched samples were compared with two-sided Wilcoxon signed-rank test. Multiple comparisons were controlled for by Benjamini-Hochberg correction.